Enalapril 20mg germed (Brasch et al, 2012; Carvalho 2010; Vazquez et al, 2010b; Yang 2009) and is a widely used antidepressant (Makris et al, 2013). A single dose of fluoxetine (50mg) has been found to improve cognition in healthy adults (Takahashi et al, 2010). Furthermore, fluoxetine has been shown to have neuroprotective effects, including the prevention of cerebral ischemic events in rodents (Bosy-Westphal et al, 2012). We therefore hypothesized that fluoxetine, alone or in combination with lisdexamfetamine dimesylate, would improve memory in healthy human adults. Materials and Methods Participants Twenty-four healthy subjects (24 female, mean ages 21.3 ± 5.1; SEM; range 18–38) completed the study. All participants were healthy and had normal cognitive function. The study was approved by local ethics committee and was conducted in accordance with the Declaration of Helsinki. Structure and Task In this study, we performed an acute test of memory in which we administered Fluoxetine (50mg) to all participants and lisdexamfetamine dimesylate (0.5–3mg) to a subsample of participants. Fluoxetine was administered on the last day of menstrual cycle to minimize its acute effects. Participants were tested individually and received verbal non-verbal questions from a computer and series of 2-back word lists. The total number of correct responses was the primary measure of memory. There were two 2-back lists of 20 words each, with the 20-word list presented every two trials in the first block and second every three trials. The order of two lists was counterbalanced across subjects. The questions per block were given randomly between subjects. The number of correct responses, list order, as well accuracy in the 911 drugstore free shipping two 20-word lists, were assessed. The first half of each block was a passive scanning task in which each participant viewed a black screen with an image of the words on an opaque background. A cursor was displayed at the center of screen, with words displayed in the same order across each trial. The remaining 30 minutes of each block were a psychomotor vigilance task in which participants were required to monitor a red target that was displayed above a target that was displayed in the background. red target was changed from every block (i.e., the task became a 3-back task) to fixed target at the beginning of third block, requiring participants to monitor the target with a cursor over the center of screen. All stimuli were presented for 200 ms, with the duration of target being 150 ms. Each trial began with a fixation point, which was then shifted to the center of screen during fixation. The fixation point was followed by the target, a 1-s fixation period, and then a 0.5-s blank period. Each target presentation was followed by a 0.5-s blank period. The task was performed for 200 ms on a computer terminal, with each participant completing a test block every 2 minutes. The computer terminal display was centered above the participants' eyes and displayed numbers '0' '1', indicating that the task began. Participants were reminded to pay attention the computer screen at all times. Data Analysis We assessed the following main effects of treatment on memory using a repeated measures analysis of variance (ANOVA) using the baseline score as an offset. The first two treatment groups tested (fluoxetine + lisdexamfetamine, and fluoxetine placebo) were collapsed into a 2-factor ANOVA with baseline memory score, as a covariate. We examined the effects of treatment on memory in a 3-factor ANOVA with treatment group, as a covariate, and baseline memory score as a covariate. We first investigated the baseline scores of each treatment group on multiple measures of memory. Subsequently, we evaluated the effects of treatment on scores all four measures of memory using a multiple regression analysis the baseline score as dependent variable. In the present study we used an intent-to-treat approach with each participant treated in all sessions. Memory scores were evaluated at baseline and can you buy real valium online the end of each treatment phase for group. In addition, we investigated the effects of treatment on memory in a post Genuine valium online hoc multiple regression analysis with Buy xanax in spain the baseline score as dependent variable and treatment group as a covariate. We used logistic regression analysis to examine the effects of fluoxetine on memory. A logistic regression analysis (Bonferroni correction for multiple comparisons) was conducted on the four memory measures. results of the regression analysis were combined to obtain a composite score for each group that was then compared.
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