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Bactrim dosing in dialysis patients with acute renal failure Lundqvist U, Lindell V, Bonta N, Hultin L, Larsson R. Hepatocellular carcinoma and drug interactions; recommendations of the European Society for Oncology. Ann Pharmacother 2014;62:1201-1205. [ PUBMED ] 3. Nabil A, El-Fadl A. Propranolol for nonalcoholic fatty liver disease. Eur J Clin Pharmacol 2016;63:631-634. The authors concluded following: "The pharmacokinetic profile of Propranolol has recently evolved from a highly specific oral drug in a limited population to potent, orally available vasopressin agonist, with potent anticholinesterase and antiadriamycinic properties. Pharmacokinetic studies the experience of patients indicate that administration Propranolol alone is not superior to the combination of Propranolol with a beta2 receptor blocker, while the potential toxicity associated with combination remains to be fully identified." 4. Jha T, Patel H, Vohra N, Shah V, Naim Q, Aulakh S. Non-alcoholic fatty liver disease associated with non-alcoholic steatohepatitis: a new clinical entity after the publication of "Treatment Non-alcoholic Fatty Liver Disease" by Jha et al. J Hepatol 2014; 62:1125-1135. 5. Cottet O, Sasse B, Chablot C. A meta-analysis of the effect statins and beta-blockers on non-alcoholic fatty liver disease in French adults: the FERMUS study (Facts and Refutations of Non-Alcoholic Fatty Liver Disease-Study Steatohepatitis), FERMUS (Federale et al, International Adderal 30 pills $191.36 $6.38 Study to Evaluate the Impact of Statin Drugs on Fatty Liver Disease), FERMUS (Federale et al, International Study to Evaluate the Impact of Beta-Blockers on Fatty Liver Disease), and FERMUS (French Interdisciplinary Association for the Study of Fatty Liver Disease). J Hepatol. 2013; 59:5-17. "A combined meta-analysis of eight studies showed that the addition of low-dose statins or beta-blocker to standard lipid lowering therapy (calculators or low-dose metoprolol) results in a lower rate of non-alcoholic fatty liver disease. However, a meta-analysis of all the studies did not show any difference in the rate at which lipid lowering agents or statins could be used in the treatment of non-alcoholic fatty liver disease." 6. Zablocki C, Chiaruzzi-Iyer U, Natarajan V, A. Effects of a short trial long-term combination with metoprolol and balsalazide on non-alcoholic fatty liver disease and the rate of recurrence in patients with the disease. Am J Med Genet B Liver Dis 2000; 65:1311S-1305S. "A trial that combines long-term and short-term oral treatment for nonalcoholic fatty liver disease was conducted in 12 patients (eight the treatment and eight in placebo group). A short-term combination (50 mg metoprolol and 300 balsalazide) significantly reduced the rate of recurrence but caused a lower level of serum beta-carotene and improved the rate of liver function tests and haemoglobin. No differences were found in the incidence of hepatocellular failure, haemoglobinemia or serum alanine aminotransferase levels between the groups." 7. Köhnert B, Jansen M, Dijk Kühnert M. Long-term combination of balsalazide with metoprolol for the treatment of nonalcoholic steatohepatitis in elderly patients. Gastroenterology 2008; 132:1581-1589. "This study shows that combining balsalazide with metoprolol as a treatment for nondiagnostic nonalcoholic steatohepatitis can significantly reduce the recurrence rate" 8. Gaudiano J, Baccaglia R, Capriolo L, Bonaccorso M. Long-term combination of metoprolol and omeprazole in nonalcoholic fatty diethyloadenitis. J Hepatol 1992; 24:1789-1795.
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