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Betametasona crema topica presentacion es. (C) In vivo micro-graphs of (A) a transcutaneous (left) and intrathecal (right) application of a single 0.5% cream, and (B) the effects of a cream containing 30% (wt:w; n=10) or 60% n=9) of C. aurax on hair thickness (A), moisture (B), and hair follicle diameters (C). Top, right, panel A shows representative superimposed images of hair samples (top). Bottom left, top, panel B shows a representative superimposed image of hair follicle diameters in representative three experiments with different C. aurax concentrations applied in the transcutaneous system. Bottom, lower right, top panel has indicated the average hair follicle diameter after each treatment in representative three additional experiments. Each image is representative of two independent experiments. **, non-significant (p>0.05); ***, significant (p<0.01), and ****, (p<0.001), with the exception of (C) (C: *p<0.05, **p<0.01, ****p<0.001) in which the C. aurax concentration increased (C: P<0.01, *p<0.05). D. Immunohistochemistry. Sections were immunohistochemically stained for keratin, β-actin, and fibronectin after treatment with 10% C. aurax.
To verify the effects of C. aurax, we examined its effects on the hair follicle by examining effects of a single topical application
ativan sublingual lorazepam 1mg 10% C. aurax on hair follicle size. We used a single 0.5% cream that showed a modest anti-inflammatory effect (Table 2). After 30 min of incubation, there were some visible changes in the hair bulb, but no significant changes were noted at the end of 15 min (Figure 1A). After application of the C. aurax cream, bulb diameter 101 generic pharmacy increased significantly from the untreated follicle length of 5 mm, and the diameter of all other follicles increased from the untreated follicle lengths of 4 mm, 3 and 2 respectively (Figure 1B 1C). Hair moisture was increased more than the moisture of control follicles, density and diameter of the hair tubules increased significantly from the untreated follicle lengths of 4 mm, 3 and 2 respectively (Figure 2). After treatment, the percentage of hair tubules that were hydrated increased significantly from the untreated follicle lengths of 10% and 20%, respectively.
Since C. aurax was present in all the hair follicles, it was assumed the effects of product were also evident in all follicles within a hair shaft. To confirm this, specimens were examined biopsied under a Leica Micro Stereomicroscope. The analysis showed that in addition to the changes C. aurax concentration, hairs were hydrated in all follicles, whereas some of the samples showed appearance inflammation (see Supplemental Text; Figure 3). The inflammation increased progressively from untreated follicle lengths in the upper part of hair shaft, although the majority of samples (Figure 3 A and 3B). Interestingly, the inflammatory changes had a significant effect on the fiber characteristics of hair shaft Ativan 2mg 90 pills US$ 420.00 US$ 4.67 (Figure 3C). In contrast, keratin content and fiber diameter in the hair shaft of both untreated follicles and the lesional did not change following C. aurax treatment. These results confirm that C. aurax was able significantly to influence the hair follicle characteristics and to improve hair moisture.
Figure 2. View largeDownload slide Photocopy of follicle length, bulb diameter, and fiber type after treatment with C. aurax cream. (A) Hairy bulb diameter after 30 min of 1% C. aurax cream application. (B) Hairy bulb diameter after 15 min of 1% C. araurax cream application. (C) Fibers with or without keratin present. Left, uninsulated, untreated follicle; top, treated with 10% C. aurax cream; right, untreated follicle.
Figure 3. View largeDownload slide Photocopy of hair follicle morphology in untreated (A), treated with an exogenous C. aurax cream (B), and.
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